| Identification | More | [Name]
Propham | [CAS]
122-42-9 | [Synonyms]
CARBANILIC ACID ISOPROPYL ESTER
INPC(R)
IPC
IPC(R)
ISO-PPC(R)
ISO-PROPYL CARBANILATE
isopropyl carbanilic acid ester
ISOPROPYL N-PHENYLCARBAMATE
ISOPROPYL PHENYLCARBAMATE
O-ISOPROPYL N-PHENYLCARBAMATE
phenylcarbamic acid 1-methylethyl ester
PROPHAM
TUBERITE
1-Methylethyl phenylcarbamate
1-methylethylphenylcarbamate[qr]
Agermin
Ban-Hoe
Beet-Kleen
Birgin
Carbamate pesticide IPC | [EINECS(EC#)]
204-542-0 | [Molecular Formula]
C10H13NO2 | [MDL Number]
MFCD00026382 | [Molecular Weight]
179.22 | [MOL File]
122-42-9.mol |
| Safety Data | Back Directory | [Hazard Codes ]
F,T,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S16:Keep away from sources of ignition-No smoking .
S7:Keep container tightly closed . | [RIDADR ]
UN 1230 3/PG 2 | [WGK Germany ]
3 | [RTECS ]
FD9100000 | [TSCA ]
Yes | [HS Code ]
29242990 | [Safety Profile]
Poison by
intraperitoneal route. Moderately toxic to
humans by ingestion. Moderately toxic
experimentally by ingestion and possibly
other routes. An experimental teratogen.
Human mutation data reported.
Questionable carcinogen with experimental
neoplastigenic data. An herbicide. When
heated to decomposition it emits toxic
fumes of NO,. See also CARBAMATES. | [Hazardous Substances Data]
122-42-9(Hazardous Substances Data) | [Toxicity]
LD50 in male, female rats (mg/kg): 3724, 4315 orally (Gaines, Linder) |
| Hazard Information | Back Directory | [General Description]
Colorless crystalline solid. | [Reactivity Profile]
PROPHAM is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates. | [Hazard]
Toxic by ingestion. | [Potential Exposure]
A potential danger to those involved
in the manufacture, formulation and application of this car-
bamate/organonitrogen grass-control herbicide. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Speed in removing material from skin
is of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If this
chemical has been inhaled, remove from exposure, begin
rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medi-
cal attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit. | [Shipping]
UN3077 Environmentally hazardous substances,
solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz-
ardous material, Technical Name Required. UN2757
Carbamate pesticides, solid, toxic, Hazard Class: 6.1;
Labels: 6.1-Poisonous materials. | [Incompatibilities]
Carbamates are incompatible with reduc-
ing agents, strong acids, oxidizing acids, peroxides, and
bases. Contact with active metals or nitrides cause the
release of flammable, and potentially explosive, hydrogen
gas. May react violently with bromine, ketones.
Incompatible with azo dyes, caustics, ammonia, amines,
boranes, hydrazines, strong | [Chemical Properties]
Propham is a colorless crystalline solid. | [Chemical Properties]
White to gray crystalline needles; odorless when pure. Mp 84C (technical grade). Soluble
in alcohol, acetone, isopropyl alcohol; insoluble in
water. | [Waste Disposal]
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations
governing storage, transportation, treatment, and waste
disposal. In accordance with 40CFR165, follow recom-
mendations for the disposal of pesticides and pesticide
containers. Must be disposed properly by following pack-
age label directions or by contacting your local or federal
environmental control agency, or by contacting your
regional EPA office. | [Uses]
Herbicide, applied as a spray to the soil. | [Uses]
Inhibitor of plant metabolism | [Uses]
Preemergence and postemergence herbicide used to control annual grass weeds in
peas, beet crops, lucerne, clover, sugar beet, beans, lettuce, flax, safflowers and lentils. | [Definition]
ChEBI: Propham is a carbamate ester that is the isopropyl ester of phenylcarbamic acid. It is a selective herbicide used for the control of annual grasses and some broad-leaf weeds and is also a growth regulator for control of sprouting in stored potatoes. It has a role as a herbicide and a plant growth retardant. It is a carbamate ester and a member of benzenes. | [Health Hazard]
Moderately toxic herbicide; exhibited low tomoderate toxicity in experimental animalswhen administered by oral, intraperitoneal,intravenous, and subcutaneous routes; skinabsorption is slow; cholinesterase inhibitor;in human ingestion can cause carbamatepoisoning, which can be lethal when takenin large amount; probable lethal oral dosein adult human estimated to be larger thanother carbamate insecticides within the range35–50 g. | [Environmental Fate]
Biological. Rajagopal et al. (1989) reported that Achromobacter sp. and an Arthrobacter sp. utilized propham as a sole carbon source. Metabolites identified were Nphenylcarbamic acid, aniline, catechol, monoisopropyl carbonate, 2-propanol and carbon
dioxide (Rajagopal et al., 1989).
Soil. Readily degraded by soil microorganisms forming aniline and carbon dioxide
(Humburg et al., 1989). The reported half-life in soil is approximately 15 and 5 days at
16 and 29°C, respectively (Hartley and Kidd, 1987).
Groundwater. According to the U.S. EPA (1986) propham has a high potential to leach
to groundwater.
Plant. The major plant metabolite which was identified from soybean plants is isopropyl N-2-hydroxycarbanilate (Hartley and Kidd, 1987; Humburg et al., 1989).
Chemical/Physical. Hydrolysis of propham yields N-phenylcarbamic acid and 2-propanol. The acid is very unstable and is spontaneously decomposed to form aniline and
carbon dioxide (Still and Herrett, 1976). Emits toxic fumes of nitrogen oxides when heated
to decomposition (Sax and Lewis, 1987). |
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