| Identification | Back Directory | [Name]
(+)-Blebbistatin | [CAS]
1177356-70-5 | [Synonyms]
(+)Blebbistatin,(+) Blebbistatin
(+)-Blebbistatin - CAS 1177356-70-5 - Calbiochem
4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aR)- | [Molecular Formula]
C18H16N2O2 | [MDL Number]
MFCD08460906 | [MOL File]
1177356-70-5.mol | [Molecular Weight]
292.33 |
| Chemical Properties | Back Directory | [Boiling point ]
507.3±60.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
-20C | [solubility ]
DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 12.5 mg/ml | [form ]
Yellow solid | [pka]
11.15±0.20(Predicted) |
| Hazard Information | Back Directory | [Chemical Properties]
Bright Yellow Solid | [Uses]
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM. A negative control for the (S)-(-)-Blebblastatin.
[a]D= +110 (c= 1.21 CHCl3)
(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one
Selective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells. | [Definition]
ChEBI: (R)-blebbistatin is the (R)-enantiomer of blebbistatin. It is a blebbistatin and a tertiary alpha-hydroxy ketone. | [storage]
Store at +4°C |
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