| Identification | Back Directory | [Name]
CHOLIC-2,2,4,4-D4 ACID | [CAS]
116380-66-6 | [Synonyms]
Cholic-d4 Acid
Cholic acid-2,2,4,4-d
Cholic Acid -[d4] (Solution)
Cholic Acid-d4 MaxSpec? Standard
5β-cholanic acid-3α,7α,12α-triol-2,2,4,4-d4
CHOLIC ACID (2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL | [Molecular Formula]
C24H36D4O5 | [MDL Number]
MFCD00190405 | [MOL File]
116380-66-6.mol | [Molecular Weight]
412.6 |
| Chemical Properties | Back Directory | [Melting point ]
200-201°C (lit.) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
Cholic acid-d4 is intended for use as an internal standard for the quantification of cholic acid (Item No. 20250) by GC- or LC-MS. Cholic acid is a primary bile acid.1 It is formed from cholesterol via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. Cholic acid is conjugated to glycine or taurine by bile acid-CoA:amino acid N-acyltransferase (BAAT) to produce glycocholic acid (GCA; Item No. 20276) and taurocholic acid (TCA; Item No. 16215), respectively, in the liver, and is transformed into the secondary bile acid deoxycholic acid (DCA; Item No. 20756) by intestinal microbiota.1,2,3 It induces C. difficile colony formation in an agar dilution assay when used at a concentration of 0.1% w/v.4 Dietary administration of cholic acid (0.4% w/w) increases serum cholesterol levels, biliary phospholipid secretion, and fecal DCA levels in rats.5 | [Uses]
Cholic Acid-d4 is a labelled analog of Cholic acid (C432600) which is a choleretic produced by, and isolated from liver cells. | [Definition]
ChEBI:Cholic acid-2,2,4,4-d4 is a bile acid. | [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|