| Identification | Back Directory | [Name]
DIGITONIN | [CAS]
11024-24-1 | [Synonyms]
DIGITIN
DIGITONIN
DigitoninGr
5% Digitonin
Digitonin USP
Digitonin, AR
DIGITONIN(RG)
DIGITONIN TECH
Digitonin ,50%
yl-(1.fwdarw.4)-
Digitonin,Digitin
galactopyranoside]
DIGITONIN CRYSTALLINE
Digitonin, High Purity
DIGITONIN WATER SOLUBLE
DIGITONIN,CRYSTAL,REAGENT
DIGITONINANALYTICAL GRADE
DIGITONIN, ALCOHOL-SOLUBLE
Digitonin, approx. 50% (TLC)
Digitonin, approx. 50% (TLC) 5GR
Digitonin, approx. 50% (TLC) 500MG
DIGITONIN, USED AS NON-IONIC DETERGE
Digitonin, approx. 50%, water soluble
DIGITONIN WATER SOLUBLERESEARCH GRADE
(1→3)]-O-β-D-glucopyranosyl-(1→4)- β-D-
DIGITONIN (DIGITIN) HIGH PURITY RECEPTOR SOLUBILIZING
beta-d-galactopyranoside,(2alpha,3beta,5alpha,15beta,25theta)-2,15-dihyd
roxyspirostan-3-ylo-beta-d-glucopyranosyl-(1.fwdarw.3)-o-beta-d-galactopyran
osyl-(1.fwdarw.2)-o-[beta-d-xylopyranosyl-(1.fwdarw.3)]-o-beta-d-glucopyranos
2α,3β,5α,15β,25R)-2,15-dihydroxyspirostan-3-yl-O-β-D-glucopyranosyl-1β-D-Galactopyranoside
Digitogenin,3-[O-β-D-glucopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→2)-O-[β-D-xylopyranosyl-
(2.alpha.,3.beta.,5.alpha.,15.beta.,25R)-2,15-dihydroxyspirostan-3-ylO-.beta.-D-glucopyranosyl-(1.beta.-D-Galactopyranoside
(2.alpha.,3.beta.,5.alpha.,15.beta.,25R)-2,15-dihydroxyspirostan-3-yl O-.beta.-D-glucopyranosyl-(1 .beta.-D-Galactopyranoside
[(25R)-2α,15β-Dihydroxy-5α-spirostan-3β-yl]4-O-[2-O-[3-O-(β-D-glucopyranosyl)-β-D-galactopyranosyl]-3-O-(β-D-xylopyranosyl)-β-D-glucopyranosyl]-β-D-galactopyranoside
25R,5ALPHA-SPIROSTAN-2ALPHA,3BETA,15BETA-TRIOL 3BETA-O-BETA-D-GALACTOPYRANOSYL-(1->3)-O-BETA-D-GALACTYOPYRANOSYL-(1->2)-O-BETA-D-[3-O-BETA-D-XYLOPYRANOSYL]-(1->4)-O-BETA-D-GALACTOPYRANOSIDE
beta.-D-Galactopyranoside, (2.alpha.,3.beta.,5.alpha.,15.beta.,25R)-2,15-dihydroxyspirostan-3-yl O-.beta.-D-glucopyranosyl-(1?3)-O-.beta.-D-galactopyranosyl-(1?2)-O-.beta.-D-xylopyranosyl-(1?3)-O-.beta.-D-glucopyranosyl-(1?4)- | [EINECS(EC#)]
234-255-6 | [Molecular Formula]
C56H92O29 | [MDL Number]
MFCD00077729 | [MOL File]
11024-24-1.mol | [Molecular Weight]
1229.31 |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
230-240 °C (dec.)(lit.)
| [alpha ]
D20 -54° (0.45 g in 15.8 ml methanol) | [Boiling point ]
788.4°C (rough estimate) | [density ]
1.1421 (rough estimate) | [refractive index ]
-52 ° (C=1, EtOH) | [storage temp. ]
Store at RT. | [solubility ]
H2O: 10 mg/mL at 95 °C hot, clear, colorless
| [form ]
White powder | [pka]
12.68±0.70(Predicted) | [color ]
white
| [optical activity]
[α]20/D 54°, c = 2.8 in methanol(lit.) | [Merck ]
14,3161 | [BRN ]
78654 | [Stability:]
Hygroscopic | [InChIKey]
FAAZZWIYYDUONB-JYIJKGCVSA-N | [EPA Substance Registry System]
Digitonin (11024-24-1) |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder | [Uses]
enhances membrane permeability | [Uses]
Natural surfactant useful for receptor solubilization and cell permeabilization, e.g., blood platelets, hepatocytes, yeast or tumor cells | [Uses]
Clinical reagent (cholesterol determination). | [General Description]
Crystals or white powder. | [Air & Water Reactions]
Forms soapy aqueous suspension . | [Reactivity Profile]
DIGITONIN is incompatible with strong oxidizing agents and strong acids. (NTP, 1992 | [Fire Hazard]
Flash point data for DIGITONIN are not available; however, DIGITONIN is probably combustible. | [Purification Methods]
This digitoxin hexa-glycoside can be recrystallised from aqueous 85% EtOH or MeOH/diethyl ether. It is purified by preparative paper chromatography and developed with the upper phase of a mixture of nBuOH/H2O/AcOH (4:5:1), and the spot (RF 0.36) is eluted with 25% CCl3CO2H in CHCl3. It has also been purified by countercurrent distribution. It forms an ethanolate, and complexes with cholesterol and other sterols. [Ruhenstroth-Bauer & Breitenfeld Hoppe Seyler's Z Physiol Chem 302 111 1955, Grisvold J Am Pharm Assoc 23 664 1934, Beilstein 19 IV 1243.] |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
23/24/25 | [Safety Statements ]
22-28-36/37-45 | [RIDADR ]
UN 3462 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
IH2050050
| [F ]
3-10 | [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
29389090 | [Safety Profile]
Poison by ingestion,
intravenous, intraperitoneal, and
subcutaneous routes. Mutation data
reported. See also DIGITALIS. When
heated to decomposition it emits acrid
smoke and irritating fumes. |
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