| Identification | More | [Name]
Ethyl isocyanate | [CAS]
109-90-0 | [Synonyms]
ETHYL ISOCYANATE
ISOCYANIC ACID ETHYL ESTER
1-Isocyanatoethane
C2H5NCO
ethane,isocyanato-
isocyanated’ethyle
isocyanato-ethan
Isocyanatoethane
isocyanato-Ethane
isocyanatoethene
Ethyl isocyanate, 98+% (Assay)
ethyl爄socyanate
ETHYL ISOCYANATE, STAB.
Ethyl isocyanate, 98+% | [EINECS(EC#)]
203-717-9 | [Molecular Formula]
C3H5NO | [MDL Number]
MFCD00002042 | [Molecular Weight]
71.08 | [MOL File]
109-90-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
<-50 | [Boiling point ]
60 °C(lit.)
| [density ]
0.898 g/mL at 25 °C(lit.)
| [vapor pressure ]
4.34 psi ( 20 °C)
| [refractive index ]
n20/D 1.381(lit.)
| [Fp ]
20 °F
| [storage temp. ]
2-8°C
| [Water Solubility ]
Insoluble | [Sensitive ]
Moisture Sensitive | [Detection Methods]
HPLC | [BRN ]
773743 | [Uses]
Pharmaceutical and pesticide intermediate. | [CAS DataBase Reference]
109-90-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethane, isocyanato-(109-90-0) | [Storage Precautions]
Store under nitrogen;Moisture sensitive | [EPA Substance Registry System]
109-90-0(EPA Substance) |
| Questions And Answer | Back Directory | [Uses]
Ethyl isocyanate is part of a group of isocyanates that react with primary and secondary amines to form urea derivatives and carbamates. Ethyl isocyanate (among other isocyanate compounds, such as toluene isocyanate) are also thought to be the most common cause of occupational asthma. |
| Safety Data | Back Directory | [Hazard Codes ]
F,T | [Risk Statements ]
R11:Highly Flammable.
R20/21:Harmful by inhalation and in contact with skin .
R25:Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R42:May cause sensitization by inhalation. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2481 3/PG 1
| [WGK Germany ]
3
| [RTECS ]
NQ8825000
| [F ]
10-19-21 | [TSCA ]
Yes | [HazardClass ]
3.1 | [PackingGroup ]
I | [HS Code ]
29291090 | [Safety Profile]
Poison by intravenous
route. Mutation data reported. A flammable
liquid. When heated to decomposition it
emits toxic fumes of NOx. See also
CYANATES. | [Hazardous Substances Data]
109-90-0(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
A colorless liquid. Less dense than water and insoluble in water. Flash point below 30°F. May irritate skin, eyes, and mucous membranes. May be lethal by Inhalation . Used to make pharmaceuticals and pesticides. | [Reactivity Profile]
When heated to decomposition ETHYL ISOCYANATE emits toxic fumes of nitrogen oxides [Sax, 9th ed., 1996, p. 1572]. | [Air & Water Reactions]
Highly flammable. Insoluble in water. ETHYL ISOCYANATE(109-90-0) may react with water to produce a corrosive liquid and carbon dioxide gas. | [Hazard]
Strong irritant to tissue. | [Health Hazard]
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Potential Exposure]
Ethyl isocyanate is used to make pharmaceuticals and pesticides | [Fire Hazard]
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
Medical observation is recommended for 24 to 48 hours
after breathing overexposure, as pulmonary edema may be
delayed. As first aid for pulmonary edema, a doctor or
authorized paramedic may consider administering a drug or
other inhalation therapy | [Shipping]
UN2481 Ethyl isocyanate, Hazard class: 6.1;
Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid,
Inhalation Hazard Zone A. Cylinders must be transported
in a secure upright position, in a well-ventilated truck.
Protect cylinder and labels from physical damage. The
owner of the compressed gas cylinder is the only entity
allowed by federal law (49CFR) to transport and refill
them. It is a violation of transportation regulations to refill
compressed gas cylinders without the express written
permission of the owner. | [Incompatibilities]
Vapor may form explosive mixture with
air. May form explosive mixture with air. Isocyanates are
highly flammable and reactive with many compounds, even
with themselves. Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Reaction with moist air, water or alcohols may form
amines and insoluble polyureas and react exothermically,
releasing toxic, corrosive or flammable gases, including
carbon dioxide; and, at the same time, may generate a violent release of heat increasing the concentration of fumes
in the air. Incompatible with amines, aldehydes, alkali
metals, ammonia, carboxylic acids, caprolactum, alkaline
materials, glycols, ketones, mercaptans, hydrides, organotin
catalysts, phenols, strong acids, strong bases, strong
reducing agents such as hydrides, urethanes, and ureas.
Elevated temperatures or contact with acids, bases, tertiary
amines, and acyl-chlorides may cause explosive polymerization. Contact Attacks some plastics, rubber and coatings.
Contact with metals may evolve flammable hydrogen
gas. May accumulate static electrical charges, and may
cause ignition of its vapors. | [Chemical Properties]
Ethyl Isocyanate is a clear, colorless liquid
with a pungent odor. | [Definition]
ChEBI: An isocyanate having an ethyl group attached to the nitrogen. | [Purification Methods]
Fractionate the isocyanate through an efficient column preferably in an inert atmosphere and store it in aliquots in sealed tubes [Bieber J Am Chem Soc 74 4700 1952, Slocombe et al. J Am Chem Soc 72 1888 1950]. [Beilstein 4 IV 402.] |
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