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ChemicalBook--->CAS DataBase List--->104594-70-9

104594-70-9

104594-70-9 Structure

104594-70-9 Structure
IdentificationMore
[Name]

Phenethyl caffeate
[CAS]

104594-70-9
[Synonyms]

CAFFEIC ACID PHENETHYL ESTER
CAFFEIC ACID PHENYLETHYL ESTER
CAPE
(E)-3-(3,4-DIHYDROXYPHENYL)-2-PROPENOIC ACID, 2-PHENYLETHYL ESTER
PHENETHYL 3,4-DIHYDROXYCINNAMATE
PHENETHYL CAFFEATE
PHENETHYL CAFFEIATE
PHENYLETHYL CAFFEATE
2-phenylethyl3-(3,4-dihydroxyphenyl)-2-propenoate
3-(3,4-dihydroxyphenyl)-2-propenoicaci2-phenylethylester
beta-phenylethylcaffeate
Caffeic Acid 2-Phenylethyl Ester
CAFFEIC ACID PHENETHYLESTER (CAPE)
CAPE,PhenethylCaffeate
CAFFEIC ACID PHENETHYL ESTER(CAPE)(P)
KAFFEESUREPHENYLETHYLESTER
CAFFEICACIDPHENYLETHERESTER
3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester
[EINECS(EC#)]

1592732-453-0
[Molecular Formula]

C17H16O4
[MDL Number]

MFCD00866470
[Molecular Weight]

284.31
[MOL File]

104594-70-9.mol
Chemical PropertiesBack Directory
[Appearance]

Off-White Solid
[Melting point ]

127-129℃
[Boiling point ]

498.6±45.0 °C(Predicted)
[density ]

1.266±0.06 g/cm3(Predicted)
[storage temp. ]

Store at 0°C
[solubility ]

Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.
[form ]

White to off-white solid
[pka]

8.46±0.20(Predicted)
[color ]

off-white
[Sensitive ]

Light Sensitive
[Usage]

Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxyg
[λmax]

323nm(lit.)
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
[Contact allergens]

Capee is one of the allergens of propolis (bee glue). It is also contained in poplar bud secretions.
[InChIKey]

SWUARLUWKZWEBQ-VQHVLOKHSA-N
[LogP]

3.734 (est)
[CAS DataBase Reference]

104594-70-9(CAS DataBase Reference)
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Uses]

antineoplastic, antiinflammatory, immunomodulator, NFkB blocker
[Uses]

Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.
[Biological Activity]

Antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF κ B activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.
[Description]

Phenylethyl caffeate is one of the allergens of propolis (bee glue); also contained in poplar-bud secretions.
[Definition]

ChEBI: Phenethyl caffeate is an alkyl caffeate ester in which 2-phenylethyl is the alkyl component. It has a role as an antineoplastic agent, an anti-inflammatory agent, an immunomodulator, a metabolite, an antioxidant, a neuroprotective agent, an antiviral agent and an antibacterial agent.
[Biochem/physiol Actions]

CAPE exhibits several properties such as anticarcinogenic, immunomodulatory activities, antioxidant, antiviral, anti-inflammatory, hypoglycaemic effect, cardioprotective and inhibits gastric secretion. It also has an inhibitory effect on fibroblasts growth factor type 2 (FGF-2), a tumor growth factor in breast cancer.
[Anticancer Research]

Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is a natural phenolcompound and an active component of propolis from honeybee hives. Torkiet al. (2017)investigated the effect of phosphatidylinositol 3-kinase/AKT/mammaliantarget of rapamycin (PI3K/Akt/mTOR) signaling pathway dual inhibitor, NVP-BEZ235,and CAPE on TNBC cell line (MDA-MB-231), stimulated withtransforming growth factor (TGF)-β1 for 14 days. CAPE in combination with NVP-BEZ235synergistically inhibited cell growth and reduced CXCR4 expression.Also, treatment of MDA-MB-231 cells with CAPE and NVP-BEZ235 time-dependentlyinhibited the expression of p-Forkhead Box O3a (FOXO3a). In a nutshell,these results indicate that tumour metastasis and progression in TNBC cellscan be effectively reduced through the concurrent use of NVP-BEZ235 and CAPE(Torki et al. 2017).
[storage]

Store at -20° C
[References]

1) Sudine et al. (1993) Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 21 329 2) Natarajan et al. (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc. Natl. Acad. Sci. USA 93 9090 3) Chiao et al. (1995). Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells; Cancer Res. 55 3576 4) Orban et.al. (2000), Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation; Neuroimmunomodulation, 7 99
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

3
[RTECS ]

UD3334375
[HS Code ]

29182900
Spectrum DetailBack Directory
[Spectrum Detail]

Phenethyl caffeate(104594-70-9)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

104594-70-9(sigmaaldrich)
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