| Identification | More | [Name]
Diclazuril | [CAS]
101831-37-2 | [Synonyms]
2,6-DICHLORO-A-(4-CHLOROPHENYL)-4(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN-2-YL)BENZENEACETONITRILE
2,6-DICHLORO-ALPHA-(4-CHLOROPHENYL)-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN-2 (3H)-YL)BENZENEACETONITRILE
2,6-dichloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3h)-yl)benzeneacetonitrile
CLINACOX
DICLAZURIL
DICLAZUTIL
clinazox
R-64433
Diclazuril premix 0.5%,1%
Diclazuril 0.5% 1% premix
Qiujia
DiclazurilCpv2000
2,6-dichloro-α-(4-chlorophenyl)-4-[4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3h)-yl]benzeneacetonitrile
2,6-Dichloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile
2,6-Dichloro-a-(4-chlorophenyl)-4-[4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl]benzeneacetonitrile
Nuoqiu
Vecoxan
2-[3,5-Dichloro-4-(α-cyano-4-chlorobenzyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione
2-[4-(4-Chloro-α-cyanobenzyl)-3,5-dichlorophenyl]-1,2,4-triazine-3,5(2H,4H)-dione | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C17H9Cl3N4O2 | [MDL Number]
MFCD00867203 | [Molecular Weight]
407.64 | [MOL File]
101831-37-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
290.5° | [density ]
1.56±0.1 g/cm3(Predicted) | [storage temp. ]
0-6°C | [solubility ]
DMF: 5mg/mL; DMSO: 5mg/mL; DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL | [form ]
neat | [pka]
5.89±0.20(Predicted) | [color ]
White to Light yellow to Light orange | [Merck ]
14,3080 | [InChI]
InChI=1S/C17H9Cl3N4O2/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24/h1-6,8,12H,(H,23,25,26) | [InChIKey]
ZSZFUDFOPOMEET-UHFFFAOYSA-N | [SMILES]
C1(C=C(C(C(C#N)C2=CC=C(Cl)C=C2)=C(Cl)C=1)Cl)N1N=CC(=O)NC1=O | [LogP]
2.439 (est) | [CAS DataBase Reference]
101831-37-2(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Description]
Diclazuril (molecular formula: C17H9Cl3N4O2, Trade name: Vecoxan) belongs to a kind of coccidiostat and potent antiprotozoal agents. It is mainly used for the treatment, control, prevention and improvements of Coccidal infections. It alleviates the symptoms of the patients by interrupting the life cycle of the parasites. It induces the morphological changes and attenuates the mitochondrial transmembrane potential in meroites. It can prevent congenital toxoplasmosis and have anticoccidial effects in vivo. It is active through oral administration.
| [References]
http://www.tabletwise.com/medicine/diclazuril
https://en.wikipedia.org/wiki/Diclazuril
http://www.abcam.com/diclazuril-ab143604.html
|
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
antiprotozoal | [Uses]
Nucleotide analog with broad-spectrum anticoccidial activity. Coccidiostat. | [Application]
Diclazuril(101831-37-2) is a less toxic, orally administered triazine antiprotozoal. It is widely used in veterinary medicine as a feed additive and veterinary drug. It is registered for oral use in broilers and lambs. Its use in cats (one dose of 25 mg/kg BW) is off-label only. It may be used clinically for the treatment of bovine protozoa. It is also used for the treatment of equine protozoan spinal cord encephalitis (EPM) caused by neuronal sarcocysts.
| [Definition]
ChEBI: 2-(4-chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]acetonitrile is a nitrile. | [Veterinary Drugs and Treatments]
Diclazuril is indicated for the treatment of equine protozoal myeloencephalitis
(EPM) caused by Sarcocystis neurona and as a coccidiostat
in broiler chickens.
Diclazuril could potentially be useful in treating coccidiosis,
Neospora caninum and Toxoplasma infections in dogs or cats. | [storage]
Store at -20°C |
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