Z-PHE-PHE-PHE-OH synthesis
1synthesis methods
- Product Name:Z-PHE-PHE-PHE-OH
- CAS Number:57092-52-1
- Molecular formula:C35H35N3O6
- Molecular Weight:593.67
Yield:57092-52-1 599 mg
Reaction Conditions:
Stage #1: N-Fmoc L-Phewith N-ethyl-N,N-diisopropylamine in dichloromethane;N,N-dimethyl-formamide at 2; for 1.08333 h;
Stage #2: with piperidine in N,N-dimethyl-formamide; for 0.333333 h;
Stage #3: N-Cbz-L-PheFurther stages;
References:
Appel, Ralph;Tacke, Sebastian;Klingauf, Jürgen;Besenius, Pol [Organic and Biomolecular Chemistry,2015,vol. 13,# 4,p. 1030 - 1039] Location in patent:supporting information