ChemicalBook CAS DataBase List Z-MEILE-OH

Z-MEILE-OH synthesis

5synthesis methods

Product Name:Z-MEILE-OH
CAS Number:4125-97-7
Molecular formula:C14H21NO2
Molecular Weight:235.32

50-00-0 Synthesis

50-00-0
865 suppliers
$10.00/25g

1859-49-0
64 suppliers
$23.30/1G

4125-97-7
50 suppliers
$22.00/250mg

Yield:4125-97-7 88.3%

Reaction Conditions:

with formic acid in water at 90; for 2 h;

Steps:

6 N-Benzyl-N-methyl-L-isoleucine (Bn-MeIle-OH)

To 110.7 g of above described N-benzyl-isoleucine (0.50 mol) were added 69.0 g formic acid (1.50 mol) and 49.4 g formaldehyde 36.5% in water (0.60 mol) and the clear, colorless reaction mixture was heated under stirring to ~90° C. for 2 h. The reaction mixture was concentrated by rotary evaporation (60° C./25 mbar) and the residue was triturated under stirring (15 min) with 250 ml acetone. After evaporation of the solvent, triturating was repeated twice using a total of 500 ml acetone. Evaporation of the solvent (50° C./10 mbar) gave 129.9 g white, crystalline residue which was stirred with 200 ml acetone for 1 h at RT and 3 h at -20° C. The crystal suspension was filtered, washed with cold acetone and dried (16 h/50° C./10 mbar) affording 103.9 g (88.3%) product as a white, crystalline powder.

References:

US2005/272665,2005,A1 Location in patent:Page/Page column 11

73-32-5 Synthesis