ChemicalBook CAS DataBase List Z-LEU-SER-OME

Z-LEU-SER-OME synthesis

4synthesis methods

Product Name:Z-LEU-SER-OME
CAS Number:40290-56-0
Molecular formula:C18H26N2O6
Molecular Weight:366.41

2018-66-8 Synthesis

2018-66-8
346 suppliers
$8.00/5g

2788-84-3 Synthesis

2788-84-3
28 suppliers
$367.00/0.25G

40290-56-0
12 suppliers
$28.60/50mg

Yield:40290-56-0 78%

Reaction Conditions:

with benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;N-ethyl-N,N-diisopropylamine in dichloromethane;water at 20; for 18 h;

Steps:

General Procedure: Peptide coupling reaction

General procedure: To a stirred solution of the N-protected amino acid derivative (1.0 eq) in dry CH2Cl2 (50-75 mM)was added EDC (1.3 eq), HOBt·H2O (1.5 eq) and DIPEA (3.0 eq). The solution was stirred at rtovernight, diluted with CH2Cl2 and the organic layer washed twice with 1M HCl(aq), saturatedaqueous NaHCO3(aq) and brine. The organic layer was dried over MgSO4(s) and the solventremoved in vacuo. See individual experiments for details.

References:

Pehere, Ashok D.;Nguyen, Steven;Garlick, Sarah K.;Wilson, Danny W.;Hudson, Irene;Sykes, Matthew J.;Morton, James D.;Abell, Andrew D. [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 2,p. 436 - 441] Location in patent:supporting information

2018-66-8 Synthesis

2018-66-8
346 suppliers
$8.00/5g

5680-80-8 Synthesis