Ufiprazole synthesis
- Product Name:Ufiprazole
- CAS Number:73590-85-9
- Molecular formula:C17H19N3O2S
- Molecular Weight:329.42
37052-78-1
649 suppliers
$11.00/25g
86604-75-3
572 suppliers
$10.00/1g
73590-85-9
474 suppliers
$30.00/10mg
Yield:73590-85-9 100%
Reaction Conditions:
with tetrabutylammomium bromide;edetate disodium;sodium hydroxide in dichloromethane;water; pH=10;pH-value;
Steps:
1.S1-1.S2; 2.S1-2.S2; 3.S1-3.S2; 1.S1-1.S2
Step S1: 80.0 g (0.36 mol) of 4-methoxy-3,5-dimethyl-2-chloromethylpyridine hydrochloride (Compound I) was added to 480 mL of dichloromethane.0.2 g of disodium edetate was dissolved in 80 mL of water and added to the reaction solution.Step S2: After stirring and dissolving, 64.0 g (0.356 mol) was added.2-mercapto-5-methoxybenzimidazole (formula II),2.0 g (0.006 mol, 2% molar equivalent) of tetrabutylammonium bromide,Sodium hydroxide adjusts the pH to 10,Stir until the reaction is over,Liquid separation,extraction,washing,dry,concentrate,a compound of formula III,Calculated in 100% yield.Sodium hydroxide adjusts the pH to 10,The specific adjustment method is:Adjust the pH value in sections,Fine-tuning with 10% sodium hydroxide in the early stage of the reaction;In the middle of the reaction, it was adjusted by using 15% sodium hydroxide.Let it reach a pH of 8,Add 15% sodium hydroxide every 10 minutes.This kind of benefit is adjusted more fully,Can better observe the effect of the adjustment,Make its PH reach 9;In the later part of the reaction, it was adjusted by using 20% hydrogen peroxide.Make it PH to 10,The way the adjustment is added when it is interrupted,Add sodium hydroxide every 20 minutes;By adjusting the pH value in sections,Thereby making the adjusted pH more precise,More saving on sodium hydroxide,Save the production costs of the enterprise.
References:
CN108409714,2018,A Location in patent:Paragraph 0049-0054; 0063-0067; 0076-0080; 0089-0093
37052-78-1
649 suppliers
$11.00/25g
84006-10-0
119 suppliers
$38.00/250mg
73590-85-9
474 suppliers
$30.00/10mg
220757-74-4
71 suppliers
$87.50/50mg
73590-85-9
474 suppliers
$30.00/10mg
142885-91-4
42 suppliers
inquiry
124-41-4
697 suppliers
$12.00/25g
73590-85-9
474 suppliers
$30.00/10mg
37052-78-1
649 suppliers
$11.00/25g
86604-78-6
295 suppliers
$7.00/5g
73590-85-9
474 suppliers
$30.00/10mg