ChemicalBook CAS DataBase List trans-2-Aminocyclopentanol hydrochloride

trans-2-Aminocyclopentanol hydrochloride synthesis

4synthesis methods

Product Name:trans-2-Aminocyclopentanol hydrochloride
CAS Number:68327-11-7
Molecular formula:C5H12ClNO
Molecular Weight:137.61

Carbamic acid, N-[(1R,2R)-2-hydroxycyclopentyl]-, phenylmethyl ester

672310-36-0
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trans-2-Aminocyclopentanol hydrochloride

68327-11-7
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$9.00/250mg

Yield:68327-11-7 79.2%

Reaction Conditions:

Stage #1: (R,R)-2-N-benzyloxycarbonylaminocyclopentanolwith hydrogen;5%-palladium/activated carbon in methanol at 50; under 15001.5 Torr; for 3 h;
Stage #2: with hydrogenchloride in methanol;water; pH=3;

Steps:

16 Example 16; Synthesis of (R,R)-2-aminocyclopentanol hydrochloride

To a 100-mL autoclave were added 15 g (70.7 mmol) of (R,R)-2-benzyloxycarbonylaminocyclopentanol and 0.3 g of 5% palladium-carbon, then 45 mL of degassed methanol were added thereto in a nitrogen atmosphere and the mixture was stirred at 50°C for 3 hours under 2 MPa of hydrogen pressure. The palladium-carbon was filtered off using Celite and concentrated hydrochloric acid was added to filtrate until the pH reached 3. The aqueous layer was concentrated to give 7.9 g of the title compound (hydrochloride). The yield was 79.2%

References:

EP1398310,2004,A1 Location in patent:Page 17

454170-16-2 Synthesis