Topiroxostat Impurity 2 synthesis
1synthesis methods
- Product Name:Topiroxostat Impurity 2
- CAS Number:445218-61-1
- Molecular formula:C12H11N5O
- Molecular Weight:241.25
Yield:-
Reaction Conditions:
Stage #1: pyridine-4-carbonitrilewith methanol;sodium methylate at 20; for 1 h;
Stage #2: isoniazid in methanol;Reflux;
References:
Sato, Takahiro;Ashizawa, Naoki;Matsumoto, Koji;Iwanaga, Takashi;Nakamura, Hiroshi;Inoue, Tsutomu;Nagata, Osamu [Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,# 21,p. 6225 - 6229] Location in patent:experimental part