Tolterodine Impurity 5 synthesis
7synthesis methods
- Product Name:Tolterodine Impurity 5
- CAS Number:173948-30-6
- Molecular formula:C15H23N
- Molecular Weight:217.35
Yield:173948-30-6 100%
Reaction Conditions:
with potassium carbonate in methanol;toluene; for 24 h;Heating / reflux;
Steps:
1
Example 1; Preparation of compound of formula II. where R1 and R? are both iPr. and R3 is Me; 51 g cinnamyl chloride is reacted with 50 g diisopropyl amine in presence of 41 g potassium carbonate in 100 ml toluene containing 25 ml methanol and after 24 hours reflux, 96 % conversion is observed. Addition of water and separating the phases, and subsequent washing and evaporation leaves a quantitative amount of the amine (72,8 g).
References:
WO2007/147547,2007,A1 Location in patent:Page/Page column 10
