Tobramycin synthesis

1synthesis methods

Product Name:Tobramycin
CAS Number:32986-56-4
Molecular formula:C18H37N5O9
Molecular Weight:467.52

Tobramycin, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-amino- 2,3,6-trideoxy-α-D-ribo-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine (3.4.7), is isolated from a culture liquid of the vital activity of the actinomycete S. tenebrarius.

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Yield:-

Steps:

11.B B.
A solution of fosfomycin/tobramycin in a 8:2 ratio was prepared. 3.1680 g of fosfomycin disodium (2.4013 g free base) was dissolved in 50 ml water. 0.6154 g of 97.5% tobramycin base (0.6000 g of pure tobramycin base) was dissolved in the fosfomycin solution.

References:

Gilead Sciences, Inc. US2011/124589, 2011, A1

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