thiazol-3-one synthesis
- Product Name:thiazol-3-one
- CAS Number:1003-07-2
- Molecular formula:C3H3NOS
- Molecular Weight:101.13
1668-10-6
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1003-07-2
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Yield: 90%
Reaction Conditions:
with sulfuryl dichloride in DMF (N,N-dimethyl-formamide) at 5 - 15; for 7.5 h;
Steps:
76 Method 76; 3-Oxo-2,3-dihydroisothiazole
Glycinamide.HCl (1 mol) was suspended in DMF (500 ml) and SO2Cl2 (300 ml) was added dropwise over 1.5 hours with cooling keeping the reaction temperature between 5-10° C. The reaction was stirred at 10-15° C. for 6 hours when water (500 ml) was added cautiously. The solid was removed by filtration and the filtrate extracted with ether (21). The Ethereal solution was washed brine (200 ml) and evaporated in vacuo to yield a pale yellow solid (132 g)-A. The aqueous layer was extracted with DCM (2*600 ml). The DCM portions were combined and washed with ether and water. The organic layer was washed brine and evaporated in vacuo to yield a cream solid (18 g)-B. A & BD were combined, dissolved in ether, dried and charcoal was added. The solution was filtered and the filtrate evaporated in vacuo to yield a pale yellow solid (104.3 g). This solid was triturated with isohexane to yield the title compound (91.3 g, 90%). Mpt: 102-5° C.
References:
Breault, Gloria Anne;Newcombe, Nicholas John;Thomas, Andrew Peter US2004/14776, 2004, A1 Location in patent:Page/Page column 37-38
![3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE](/CAS/GIF/1002-19-3.gif)
1002-19-3
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25629-58-7
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1003-07-2
119 suppliers
$35.00/100mg
2807-36-5
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2682-21-5
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2682-36-2
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1003-07-2
119 suppliers
$35.00/100mg