TETRAMETHYLURIC ACID synthesis
11synthesis methods
- Product Name:TETRAMETHYLURIC ACID
- CAS Number:2309-49-1
- Molecular formula:C9H12N4O3
- Molecular Weight:224.22
Yield:3404-56-6 90%
Reaction Conditions:
with potassium tert-butylate in acetonitrile at 20 - 90; for 12 h;
Steps:
13
The cyclate obtained in the previous step (9.11 g, 43 mmol) was suspended in acetonitrile, and potassium t-butoxide (52 mmol) was added. Methyl iodide (52 mmol) was added at 20-30 °C. The reaction was carried out at 80-90 ° C for 12 hours, and the basic reaction of the raw materials was completed. Concentrate and beat with water and methanol in sequence. After drying, 8.7 g of white tetramethyl uric acid was obtained in a yield of 90%. The purity is 98%.
References:
CN108912121,2018,A Location in patent:Paragraph 0163; 0164; 0168