ChemicalBook CAS DataBase List tert-Butylisocyanate

tert-Butylisocyanate synthesis

10synthesis methods

Product Name:tert-Butylisocyanate
CAS Number:1609-86-5
Molecular formula:C5H9NO
Molecular Weight:99.13

4083-64-1 Synthesis

4083-64-1
364 suppliers
$7.00/25g

75-64-9
429 suppliers
$10.00/10g

1609-86-5
203 suppliers
$28.10/5g

Yield:1609-86-5 80%

Reaction Conditions:

Stage #1:Tosyl isocyanate;tert-butylamine in 5,5-dimethyl-1,3-cyclohexadiene at 0; for 4 h;Reflux;
Stage #2: in 5,5-dimethyl-1,3-cyclohexadiene at 83 - 90;Solvent;

Steps:

1
36.6 g (0.50 mol) of t-butylamine was added dropwise to the above first reaction solution at 0 ° C.Heating and refluxing for more than 4 hours,A second reaction liquid was obtained.Sampling and testing, the mass content of urea in the second reaction solution is ≤1%.
Distilling the second reaction liquid to collect a fraction of 83 ° C to 90 ° C,40.4 g of t-butyl isocyanate were obtained.
The purity of the tert-butyl isocyanate was 98.3% and the yield was 80%.
A mixture of 582 g of rectified residual material xylene and p-toluenesulfonamide was recycled.

References:

Hunan Guofa Fine Chemical Technology Co., Ltd.;Chen Rugui;Wu Denglin;Li Qi;Gong Bingyan CN108395383, 2018, A Location in patent:Paragraph 0053-0088