TERT-BUTYL 3-METHYL-4-NITROBENZOATE synthesis
- Product Name:TERT-BUTYL 3-METHYL-4-NITROBENZOATE
- CAS Number:147290-67-3
- Molecular formula:C12H15NO4
- Molecular Weight:237.25
3113-71-1
468 suppliers
$6.00/25g
147290-67-3
12 suppliers
$495.88/5MG
Yield:147290-67-3 97%
Reaction Conditions:
with pyridine;benzenesulfonyl chloride in hexane;ethyl acetate;tert-butyl alcohol;
Steps:
8.a a
a t-butyl 3-methyl-4-nitrobenzoate 3-Methyl-4-nitrobenzoic acid (500 g, 2.76 mol) was added to pyridine (1.25 L) and stirred until it dissolved. Benzenesulfonyl chloride (609 g, 3.45 mol) was added rapidly while maintaining the internal temperature <30° C. with an ice bath. A precipitate formed towards the end of the addition and pyridine (500 mL) was added to improve stirring. The mixture was stirred for 30 min and t-butanol (523 mL) was added dropwise over 30 min at <30° C. The mixture was stirred for 2 h, dissolved in hexane:ethyl acetate (4:1; 2.5 L) and the resulting mixture was extracted with water. The organic phase was concentrated to give a light yellow oil which crystallized on cooling to give the title compound (635 g, 97%). mp 56-58° C.
References:
US6117866,2000,A
3113-71-1
468 suppliers
$6.00/25g
75-65-0
753 suppliers
$10.00/10ml
147290-67-3
12 suppliers
$495.88/5MG