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7721-49-5

β-t-butylpyrrole synthesis

5synthesis methods
-

Yield:7721-49-5 78.4%

Reaction Conditions:

with ethanol;water;potassium hydroxide for 5 h;Reflux;

Steps:

3 Step 3.

To a solution of 3-(tert-Butyl)-1-(phenylsulfonyl)-1H-pyrrole (6.0 g, 22.8 mmol) in EtOH/H2O (60 mL/60 mL) was added KOH (12.8 g, 228 mmol). The mixture was stirred at reflux for 5 h. Then the solvent was removed under reduced pressure. The residue was taken in water (50 mL). The aqueous solution was extracted with DCM (20 mL x 3). The organic layer was washed with brine, dried Na2SO4, filtered and concentrated. The residue was purified by SGC (PE/EA = 5:1) to give 3-(tert-butyl)-1H-pyrrole (2.20 g, 78.4% yield) as a yellow oil.

References:

WO2021/97057,2021,A1 Location in patent:Page/Page column 418