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ChemicalBook CAS DataBase List sulfapyrazole
852-19-7

sulfapyrazole synthesis

4synthesis methods
-

Yield: 91%

Reaction Conditions:

with water;sodium hydroxide for 2 h;Reflux;

Steps:

General procedure for the synthesis of 16a-f
General procedure: The corresponding amide 15a-f was heated to reflux in 2N NaOH aqueous solution (6ml) for 2 h. The reaction mixture was filtered and the filtrate was acidified with 1N HClto pH = 5. The precipitated solid was filtered to obtain the compounds 16a-f.

References:

Chen, Hui;Wang, Bin;Li, Peng;Yan, Hong;Li, Gang;Huang, Haihong;Lu, Yu [Bioorganic and Medicinal Chemistry Letters,2021,vol. 40,art. no. 127924] Location in patent:supporting information

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