Semax synthesis

8synthesis methods

Product Name:Semax
CAS Number:80714-61-0
Molecular formula:C37H51N9O10S
Molecular Weight:813.92

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Yield:-

Steps:

Multi-step reaction with 9 steps
1: 53 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, triethylamine / tetrahydrofuran / 48 h / Ambient temperature
2: 100 percent / CH₂Cl₂ / 0.67 h / Ambient temperature
3: 70 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, triethylamine / tetrahydrofuran / 48 h / Ambient temperature
4: CH₂Cl₂ / Ambient temperature
5: 75 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, triethylamine / tetrahydrofuran / 48 h / Ambient temperature
6: CH₂Cl₂ / Ambient temperature
7: 1.) aq. H₂SO₄, 2.) 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, triethylamine / 2.) THF, room temp., 3 days
8: 76 percent / 1,4-cyclohexadiene / Pd-black / ethanol / 2 h / Heating
9: 57 percent / 1 N HCl / acetic acid / 0.5 h / Ambient temperature

References:

Ponomareva-Stepnaya, M. A.;Nezavibat'ko, V. N.;Antonova, L. V.;Andreeva, L. A.;Alfeeva, L. Yu.;et al. [Pharmaceutical Chemistry Journal,1984,vol. 18,# 7,p. 445 - 450][Khimiko-Farmatsevticheskii Zhurnal,1986,vol. 18,# 7,p. 790 - 795]