Ranitidine synthesis

1synthesis methods

Product Name:Ranitidine
CAS Number:66357-35-5
Molecular formula:C13H22N4O3S
Molecular Weight:314.4

Ranitidine, N[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]- N′-methyl-2-nitro-1,1-ethendiamine (16.2.8), is synthesized from furfuryl alcohol, which undergoes aminomethylation reaction using dimethylamine and paraform, which form 5- (dimethylaminomethyl)furfuryl alcohol (16.2.6). Further reaction with 2-mercaptoethylamine hydrochloride gives a product of substitution of the hydroxyl group in (16.2.6), 5-dimethylaminomethyl-2-(2′-aminoethyl)thiomethylfurane (16.2.7). Reacting this with Nmethyl- 1-methylthio-2-nitroethenaamine gives ranitidine (16.2.8).

61832-41-5 Synthesis

N-Methyl-1-(methylthio)-2-nitroethylen-1-amine

61832-41-5
233 suppliers
$19.60/10g

5-[[(2-Aminoethyl)thio]methyl]-N,N-dimethyl-2-furfurylamine

66356-53-4
181 suppliers
$53.02/5gm:

66357-35-5
229 suppliers
$31.69/1 g

Yield:66357-35-5 92%

Reaction Conditions:

in water at 55;

References:

Galkin, Konstantin I.;Krivodaeva, Elena A.;Romashov, Leonid V.;Zalesskiy, Sergey S.;Kachala, Vadim V.;Burykina, Julia V.;Ananikov, Valentine P. [Angewandte Chemie - International Edition,2016,vol. 55,# 29,p. 8338 - 8342][Angew. Chem.,2016,vol. 128,# 29,p. 8478 - 8482,5] Location in patent:supporting information

Ranitidine Related Search:

Ranitidine Hydrochloride Propyl gallate N-Methyl-1-(methylthio)-2-nitroethylen-1-amine