天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List (R)-(+)-1,2-EPOXYDODECANE
109856-85-1

(R)-(+)-1,2-EPOXYDODECANE synthesis

9synthesis methods
2-Dodecanol, 1-chloro-, (2R)-

1146207-13-7
0 suppliers
inquiry

(R)-(+)-1,2-EPOXYDODECANE

109856-85-1
11 suppliers
inquiry

-

Yield:109856-85-1 95%

Reaction Conditions:

with sodium hydroxide in tetrahydrofuran;methanol at 0 - 20; for 3 h;Temperature;Concentration;

Steps:

7

[00215j Synthesis of compound 5.1: To a solution of 4.1 (243.49 g) in 1:2.6 MeOH-THF (3.6 L) stirred at 0 °C was slowly added aqueous NaOH solution (1.5 M, 0.89 L, 1.33 mole). The resulting mixture was allowed to warm up and stirred at room temperature for 3 h. TLC analysis showed complete disappearance of 4.1. Organic solvents were evaporated, and the aqueous layer was extracted with Et20 (1 L + 500 mL x 2). The organic extracts were combined, washed with brine (600 mL), and dried over anhydrous magnesium sulfate. Solvents were evaporated under vacuum to give a residue which was purified on silica gel column (hexanes to 10% EtOAc/hexanes) to provide the epoxide 5.1 (193.7 g, 95%) as a light yellow oil.

References:

WO2015/200465,2015,A1 Location in patent:Paragraph 00215

(R)-(+)-1,2-EPOXYDODECANE Related Search: