Quizalofop-P synthesis
- Product Name:Quizalofop-P
- CAS Number:94051-08-8
- Molecular formula:C17H13ClN2O4
- Molecular Weight:344.75
18671-97-1
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$7.00/250mg
94050-90-5
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$6.00/10g
94051-08-8
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$95.00/10mg
Yield:94051-08-8 97%
Reaction Conditions:
Stage #1:(R)-2-(4-hydroxyphenoxy)propionic acid with potassium carbonate in N,N-dimethyl-formamide at 20 - 75; for 2 h;
Stage #2:2,6-dichloroquinoxaline in N,N-dimethyl-formamide at 145; for 6 h;
Steps:
4
N, N-dimethylformamide (DMF) (40 mL) was added to a 100 mL reaction flask, and (R) -2- (4-hydroxyphenoxy) Acid (3.0 g, 0.02 mol) was added to the reaction flask and stirred to dissolve. At room temperature, potassium carbonate (4.46 g, 0.033 mol), stirring was continued for 15 to 30 minutes, the temperature was raised to 75 ° C, and the mixture was stirred for 2 hours. 2,6-dichloroquinoxaline (3.28 g, 0.02 mol) and the temperature was raised to 145 ° C for 6 h. After completion of the reaction, the mixture was cooled to room temperature, and the reaction solution was poured into ice water (250 mL) and dropped Hydrochloric acid to pH = 4 to 5, filtered, washed with water and dried to give a yellow solid (R) -2- (4 - ((6-chloroquinoxalin-2-yl) oxy) Phenoxy) propionic acid, 5.55 g, The yield was 97%.
References:
China Three Gorges University;Liu Qixing;Zhou Haifeng;Wang Chunqin;Chen Junbo;Peng Yuqi CN106632258, 2017, A Location in patent:Paragraph 0040; 0041
57057-80-4
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$27.00/1g
![6-CHLORO-2-[(4-HYDROXYPHENYL)OXY]QUINOXALINE](/CAS/GIF/76578-79-5.gif)
76578-79-5
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94051-08-8
75 suppliers
$95.00/10mg
76578-14-8
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$38.60/50mg
94051-08-8
75 suppliers
$95.00/10mg