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ChemicalBook CAS DataBase List quinoline-2,4-diol
70254-44-3

quinoline-2,4-diol synthesis

12synthesis methods
73776-19-9 Synthesis
3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-2-oxo-, Methyl ester

73776-19-9
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Yield:70254-44-3 99.1%

Reaction Conditions:

with potassium hydroxide in water; for 15 h;Heating;

Steps:

3 Synthesis of 4-hydroxy-2-quinolinone

250mL round-bottom flask was added 4.38g (20.0mmol) Intermediate I-c2 and 100mL water was added 3.36g (60.0mmol) of potassium hydroxide was heated for 15h cooled to room temperature, Xeon adjusted with dilute hydrochloric acid and produce a large number of white solid, filtration, the solid was washed successively with water and ethanol, Drying to give white solid I-c3 3.21g, yield 99.1%,

References:

CN103508950,2016,B Location in patent:Paragraph 0073; 0076