Pyrimidine, 2-(ethylthio)- (7CI,8CI,9CI) synthesis

9synthesis methods

Product Name:Pyrimidine, 2-(ethylthio)- (7CI,8CI,9CI)
CAS Number:10132-25-9
Molecular formula:C6H8N2S
Molecular Weight:140.21

4595-60-2 Synthesis

4595-60-2
354 suppliers
$8.00/5g

75-08-1 Synthesis

75-08-1
231 suppliers
$16.19/25ml

Pyrimidine, 2-(ethylthio)- (7CI,8CI,9CI)

10132-25-9
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Yield:10132-25-9 90%

Reaction Conditions:

Stage #1: ethanethiolwith sodium hydride in tetrahydrofuran at 20; for 1 h;Inert atmosphere;
Stage #2: 2-bromopyrimidinewith di-μ-iodobis(tri-t-butylphosphino)dipalladium(l) in tetrahydrofuran;toluene at 40; for 12 h;Inert atmosphere;

References:

Scattolin, Thomas;Senol, Erdem;Yin, Guoyin;Guo, Qianqian;Schoenebeck, Franziska [Angewandte Chemie - International Edition,2018,vol. 57,# 38,p. 12425 - 12429][Angew. Chem.,2018,vol. 130,# 38,p. 12605 - 12609,5] Location in patent:supporting information