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ChemicalBook CAS DataBase List pyrido[3,2-d]pyridazin-8(7H)-one
15370-81-7

pyrido[3,2-d]pyridazin-8(7H)-one synthesis

3synthesis methods
3-Pyridinecarboxylic acid, 2-(dibromomethyl)-, methyl ester

1447588-21-7
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Yield:15370-81-7 95%

Reaction Conditions:

with hydrazine hydrate in methanol; for 5 h;Reflux;

Steps:

4.7 General procedure for the preparation of 5-8

General procedure: A solution of 25-28 (3.08g, 0.01mol) and hydrazine hydrate (2.00g, 0.04mol) in methanol (50mL) was stirred under reflux for 5h. The solvent was evaporated under reduced pressure, and the residue was recrystallized from MeOH-H2O (9:1).

References:

Yaremenko, Anatoliy G.;Volochnyuk, Dmitriy M.;Shelyakin, Vyacheslav V.;Grygorenko, Oleksandr O. [Tetrahedron,2013,vol. 69,# 33,p. 6799 - 6803]

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