ChemicalBook CAS DataBase List Pyridine, 3-bromo-6-methoxy-2,4-dimethyl- (9CI)

Pyridine, 3-bromo-6-methoxy-2,4-dimethyl- (9CI) synthesis

5synthesis methods

Product Name:Pyridine, 3-bromo-6-methoxy-2,4-dimethyl- (9CI)
CAS Number:819069-57-3
Molecular formula:C8H10BrNO
Molecular Weight:216.08

918145-29-6 Synthesis

918145-29-6
45 suppliers
$30.00/100mg

124-41-4 Synthesis

124-41-4
697 suppliers
$12.00/25g

Pyridine, 3-bromo-6-methoxy-2,4-dimethyl- (9CI)

819069-57-3
36 suppliers
$65.00/10mg

Yield:819069-57-3 94%

Reaction Conditions:

in methanol at 100; for 2 h;

Steps:

87.1 Step 1: Synthesis of 3-bromo-6-methoxy-2,4-dimethyl-pyridine

A mixture of 3-bromo-6-chloro-2,4-dimethyl-pyridine (900 mg, 4.08 mmol) and sodium methanolate in methanol (9.0 mL, 30% w/w in methanol) was stirred at 100 °C for 2 hours. After cooling to room temperature, the reaction mixture was quenched with water and extracted with ethyl acetate three times. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the title compound as a light yellow oil. Yield: 830 mg, 94%. LCMS (ESI) m/z: 215.9 (M+H).

References:

WO2022/109492,2022,A1 Location in patent:Page/Page column 379

89694-55-3 Synthesis