ChemicalBook CAS DataBase List Pyridine,3,4-bis(chloromethyl)-(9CI)

Pyridine,3,4-bis(chloromethyl)-(9CI) synthesis

5synthesis methods

Product Name:Pyridine,3,4-bis(chloromethyl)-(9CI)
CAS Number:38070-81-4
Molecular formula:C7H7Cl2N
Molecular Weight:176.04

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Yield:38070-81-4 52 %

Reaction Conditions:

with N-chloro-succinimide;dibenzoyl peroxide in tetrachloromethane;Reflux;UV-irradiation;

Steps:

2 Embodiment 2: the preparation of 3,4-dichloromethylpyridine

Add 10.7g (100mmol) 3,4-lutidine, 75g (420 mmol) N-chlorosuccinimide, 80mg dibenzoyl peroxide, 300ml carbon tetrachloride to a 1L reaction flask , stirred, heated to reflux, and irradiated with a 100W 395nm ultraviolet lamp, and reacted overnight. The reaction liquid was filtered, and the filtrate was washed with saturated sodium carbonate water, dried over anhydrous sodium sulfate, spin-dried to dry the solvent, and recrystallized twice with dichloromethane/n-hexane to obtain 9.2 g of solids, with a yield of 52%.

References:

CN115772195,2023,A Location in patent:Paragraph 0055-0057

38070-80-3 Synthesis