ChemicalBook CAS DataBase List (PYRAZIN-2-YLMETHYL)AMINE

(PYRAZIN-2-YLMETHYL)AMINE synthesis

5synthesis methods

Product Name:(PYRAZIN-2-YLMETHYL)AMINE
CAS Number:20010-99-5
Molecular formula:C5H7N3
Molecular Weight:109.13

19847-12-2
342 suppliers
$6.00/5g

20010-99-5
168 suppliers
$11.00/1g

Yield:20010-99-5 100%

Reaction Conditions:

with Ni-doped silica;hydrogen in toluene at 140; under 38002.6 Torr; for 4 h;Autoclave;Inert atmosphere;

Steps:

7 The synthesis of 2-aminomethyl pyradine
The synthesis of 2-aminomethyl pyradine(2-AMPZ) was carried out by a method shown below, byreference to the method described in literature (JP A 2001-894594). 2-cyanopyradine used was from Sigma-Aldrich Co.LLC.1.05 g of 2-cyanopyradine (10 mmol) and 100mg of60 wt %-Ni/5i02 were placed in an autoclave (5U53 16) with20 mL of toluene and replaced with argon gas. This waspressurized with hydrogen gas to 50 atm, stirred at 140°C. for4 hours. The reaction solution was filtered and concentratedto give 2-aminomethyl pyradine (2-AMPZ) quantitatively.10152] ‘H-NMR spectrum (399.78 MHz, CDC13):?8.60-8.45 (m, 3H), 4.07 (s, 2H), 1.79 (br, 2H)

References:

KATAYAMA, TAKEAKI;TSUTSUMI, KUNIHIKO;MURATA, KUNIHIKO;OHKUMA, TAKESHI;ARAI, NORIYOSHI US2015/31920, 2015, A1 Location in patent:Paragraph 0150; 0151; 0152

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