ChemicalBook CAS DataBase List PHYTANIC ACID

PHYTANIC ACID synthesis

5synthesis methods

Product Name:PHYTANIC ACID
CAS Number:14721-66-5
Molecular formula:C20H40O2
Molecular Weight:312.53

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Yield:14721-66-5 72.3%

Reaction Conditions:

with sodium disulfite;chromic acid;acetic acid in [⁽²⁾H₆]acetone;water

Steps:

P.17 Synthesis of 3,7,11,15-tetramethyl-1-hexadecanoic acid
Preparation Example 17
Synthesis of 3,7,11,15-tetramethyl-1-hexadecanoic acid
3,7,11,15-Tetramethyl-hexadecan-1-ol (8.96 g, 30.0 mmol) was dissolved in a mixed solvent of acetone (360 ml) and acetic acid (180 ml), a solution of anhydrous chromic acid (7.27 g, 72.7 mmol) in water (9.0 ml) was added dropwise, and the mixture was stirred at room temperature for 1 hr.
A solution of sodium disulfite (100 g, 526 mmol) in water (450 ml) was added to the reaction mixture after completion of the reaction, the mixture was stirred at room temperature overnight and extracted 6 times with diethyl ether (135 ml).
The solvent of the obtained organic layer was evaporated under reduced pressure.
Diethylether (450 ml) and water (150 ml) were added to the oil after concentration to allow partitioning, and the aqueous layer was extracted 3 times with ethyl acetate (150 ml).
The combined organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure.
The oil (10.1 g) after concentration was purified by chromatography (silica gel; 250 g, eluate; 50:1→3:1 hexane-ethyl acetate) to give the title compound (6.78 g, 72.3%) as a pale-blue oil.

References:

Hirai, Kunihiro;Katayama, Satoshi;Torii, Takayoshi;Nakaya, Ryotaro;Takahashi, Daisuke US2013/267697, 2013, A1 Location in patent:Page/Page column

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645-72-7
19 suppliers
inquiry

14721-66-5
62 suppliers
$75.00/5mg

References

7541-49-3 Synthesis