Octabenzone synthesis
- Product Name:Octabenzone
- CAS Number:1843-05-6
- Molecular formula:C21H26O3
- Molecular Weight:326.43
? in the presence of a mixture of sodium carbonate, triethylamine and potassium iodide in refluxing butanol for 15 h (90%);
? in the presence of potassium carbonate in cyclohexanone at 145° for 5 h (66%);
? in the presence of potassium hydroxide and antimony triiodide in diethylene glycol at 150° for 1 h (93%);
? in the presence of sodium bicarbonate and potassium iodide in 1-methylpyrrolidone for 2 h at 150° (96%).
Yield:1843-05-6 95.3%
Reaction Conditions:
with sodium carbonate;potassium carbonate at 98 - 120;Temperature;
Steps:
1-3
Put 160.0g of chloro-n-octane into a reactor equipped with a thermometer and a stirring device. The temperature is raised to 98°C, and 110.0g of 2,4-dihydroxybenzophenone, 15.0g of PEG-600, and potassium carbonate are successively added under stirring. 0.86g, 31.0g of sodium carbonate, continue to stir and heat to 120°C after casting, reflux and separate water, cool down after reflux and separation, add appropriate amount of water to the resulting system for washing, stand still for layering, oil layer distillation to obtain product UV -531, the purity by gas chromatography was 99.1%, and the yield was 95.3%.
References:
CN112142581,2020,A Location in patent:Paragraph 0018-0023