Yield:-

Reaction Conditions:

with hydrogenchloride in water;

Steps:

12.f (f)

(f) O-Methyl-D-tyrosine hydrochloride N-Acetyl-O-methyl-D-tyrosine, 24 g. is heated in 100 ml. of water and 100 ml. of concentrated hydrochloric acid for seven hours on a steam bath and let cool to room temperature overnight. The flask is swirled gently and the product crystallizes. It is separated by filtration, washed with a small amount of isopropanol, then with ether and dried to give 16.1 g. of the above named compound, [α]_D²³ +7.4° (c 2.02, DMF).

References:

US4111923,1978,A