ChemicalBook CAS DataBase List N1-(2,4-DICHLOROPHENYL)BENZAMIDE

N1-(2,4-DICHLOROPHENYL)BENZAMIDE synthesis

9synthesis methods

Product Name:N1-(2,4-DICHLOROPHENYL)BENZAMIDE
CAS Number:10286-76-7
Molecular formula:C13H9Cl2NO
Molecular Weight:266.12

2866-82-2 Synthesis

2866-82-2
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10286-76-7
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Yield:10286-76-7 85%

Reaction Conditions:

with iodosylbenzene;anhydrous zinc chloride in 2,2,2-trifluoroethanol at 45; for 3 h;Schlenk technique;Green chemistry;

Steps:

3.2. general procedure for the synthesis of 2 and 3

General procedure: A Schlenk tube with a magnetic stir bar was charged withamide 1 (0.50 mmol), ZnCl2 (0.50 mmol, 68.0 mg), 2,2,2-trifluoroethanol (2.0 mL). Then, PhI=O (0.60 mmol, 132.0mg) was added. The reaction mixture was then heated to 45oC and stirred for indicated hours. The reaction mixture wasthen allowed to cool to ambient temperature, and all of thevolatiles were removed under vacuum; the crude productwas purified on flash chromatography, eluting with petroleum/ethyl acetate, to provide products 2 or 3.

References:

Liu, Haixuan;Sha, Qiang [Letters in Organic Chemistry,2022,vol. 19,# 3,p. 173 - 180]

583-04-0 Synthesis