ChemicalBook CAS DataBase List N-TERT-BUTYL-ALPHA-PHENYLNITRONE

N-TERT-BUTYL-ALPHA-PHENYLNITRONE synthesis

10synthesis methods

Product Name:N-TERT-BUTYL-ALPHA-PHENYLNITRONE
CAS Number:3376-24-7
Molecular formula:C11H15NO
Molecular Weight:177.24

3378-72-1 Synthesis

3378-72-1
259 suppliers
$8.00/5g

3376-24-7
139 suppliers
$25.00/500mg

Yield:3376-24-7 96%

Reaction Conditions:

with dihydrogen peroxide in acetonitrile at 25; for 3 h;Reagent/catalyst;

Steps:

1 Embodiment 1
N-tert-butyl benzyl amine method of preparing nitrone, its reaction general formula type are as follows: Comprises the following steps: (1) the 2mmol N-tert-butyl benzyl amine of added to 25 ml round-bottom flask, by adding acetonitrile 3 ml, add catalyst WO _3-x 0.02mmol, 30% hydrogen peroxide solution of 5mmol, stirring 25 °C 3h, get mixed solution; (2) step (1) with water to obtain a mixed solution of releases to 20 ml, dichloromethane extraction, concentrated to remove the solvent, column chromatography separation, 200-300 purpose silica gel column, eluting agent is petroleum ether and ethyl acetate, the volume of the two ratio of 2:1, to obtain white solid, yield 96%.

References:

Nanyang Normal University;Bao, keyan;Mao, wutao;Xu, kun;Li, zhengdao;Ye, liqun;Xie, haiquan;Cao, fengpu;Li, beibei CN105566169, 2016, A Location in patent:Paragraph 0017

FullText