N-(pyridin-2-ylmethyl)propan-1-amine synthesis
- Product Name:N-(pyridin-2-ylmethyl)propan-1-amine
- CAS Number:51639-59-9
- Molecular formula:C9H14N2
- Molecular Weight:150.22
1121-60-4
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51639-59-9
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Yield:51639-59-9 92.2%
Reaction Conditions:
Stage #1: pyridine-2-carbaldehyde;propylaminewith sodium sulfate in dichloromethane at 20;
Stage #2: with methanol;sodium tetrahydroborate at 20; for 1 h;Cooling with ice;
Steps:
14.1 step 1:Synthesis of N-(pyridin-2-ylmethyl)propyl-1-ammonia
2-pyridinecarboxaldehyde (0.9 mL, 9.4 mmol) was added to a 50 mL single-mouth bottle.N-propylamine (919 μL, 11.2 mmol), anhydrous sodium sulfate 1 g,15 mL of dichloromethane was stirred at room temperature overnight. Filter and spin the solvent,After adding 15 mL of methanol, sodium borohydride (178 mg, 4.68 mmol) was added under ice-cooling, and the mixture was stirred at room temperature for 1 hour, and the reaction was completed by TLC.The reaction was quenched with saturated aqueous sodium carbonate and extracted with ethyl acetate.Dry over anhydrous sodium sulfate, and combine the organic solvent and spin dry.Made a colorless oil 1.3g,The yield was 92.2%.
References:
CN109206346,2019,A Location in patent:Paragraph 0200; 0203; 0204; 0205
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51639-59-9
13 suppliers
$98.00/1g
1121-60-4
508 suppliers
$10.60/10gm:
51639-59-9
13 suppliers
$98.00/1g