ChemicalBook CAS DataBase List N-(p-Aminobenzoyl)glutamic acid

N-(p-Aminobenzoyl)glutamic acid synthesis

12synthesis methods

Product Name:N-(p-Aminobenzoyl)glutamic acid
CAS Number:4271-30-1
Molecular formula:C12H14N2O5
Molecular Weight:266.25

6758-40-3 Synthesis

6758-40-3
92 suppliers
inquiry

4271-30-1
379 suppliers
$6.00/1g

Yield:4271-30-1 96.58%

Reaction Conditions:

with palladium 10% on activated carbon;ammsnium formate in methanol at 20; for 0.5 h;Time;Concentration;

Steps:

1.3 Example 1 Preparation of (3) N- amino-benzoyl -L- glutamic acid

Reaction vessel was added N- Nitrobenzoylhydrazone -L- glutamic acid 27.23g (0.1mol), methanol 118g, turn on stirring, was added 10% Pd / C0.59g, then slowly added ammonium formate 18.92g (0.3mol), stirred at room temperature for 30 minutes, filtered, recovered Pd / C next applied, the filtrate was adjusted with hydrochloric acid in methanol PH = 3, the precipitated crystals were filtered after 30 minutes resting, a small amount of methanol, washed, dried, to give N - amino-benzoyl -L- glutamic acid 25.75g, HPLC purity of 99.88%, a yield of 96.58%, the total yield of 95.64% (with on-nitro benzoic acid).

References:

CN105439895,2016,A Location in patent:Paragraph 0029; 0030