ChemicalBook CAS DataBase List N-BUTYL 4-NITROBENZOATE

N-BUTYL 4-NITROBENZOATE synthesis

12synthesis methods

Product Name:N-BUTYL 4-NITROBENZOATE
CAS Number:120-48-9
Molecular formula:C11H13NO4
Molecular Weight:223.23

71-36-3 Synthesis

71-36-3
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62-23-7 Synthesis

62-23-7
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120-48-9
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Yield:120-48-9 99.1%

Reaction Conditions:

with sulfuric acid at 120; for 12 h;

Steps:

1.1

1 Add 200 g of n-butyl p-nitrobenzoate (0.9 mol), 73.3 g of n-butanol (0.99 mol), and 167 g of p-nitrobenzoic acid (1 mol) to the esterification reactor, and slowly add dropwise with stirring. 1.9 g of concentrated sulfuric acid was added to reflux (120 ± 1 ° C) after heating, and after 12 h of heat preservation reaction, the temperature was raised to 128 ± 1 ° C, and a total of 17.8 g of water was separated. After completion of the reaction, the mixture was cooled to 35 ± 1 ° C, neutralized with a sodium carbonate aqueous solution to pH = 7.5 ± 0.1, and allowed to stand for separation to obtain 421 g of the lower organic relative n-butyl nitrobenzoate, the yield was 99.1%, and the purity was 99.26% (HPLC).

References:

CN110343051,2019,A Location in patent:Paragraph 0014; 0015

201230-82-2 Synthesis