Tert-butyl bis(2-chloroethyl)carbamate synthesis
- Product Name:Tert-butyl bis(2-chloroethyl)carbamate
- CAS Number:118753-70-1
- Molecular formula:C9H17Cl2NO2
- Molecular Weight:242.14
24424-99-5
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821-48-7
558 suppliers
$6.00/25g
118753-70-1
177 suppliers
$6.00/1g
Yield:118753-70-1 100%
Reaction Conditions:
in dichloromethane
Steps:
35.B B.
B. N-tert-Butoxycarbonyl-bis(2-chloroethyl)amine To a mixture of 17.85 g (100 mmole) of bis(2-chloroethyl)amine hydrochloride and 24.0 g (110 mmole) of di-tert-butyl dicarbonate in 100 ml of dichloromethane was added a solution of 15.3 ml (110 mmole) of trietylamine in 50 ml of dichloromethane dropwise over 30 minutes. The mixture was stirred at room temperature for 24 hours and was poured into water. The organic layer was dried over magnesium sulfate and was filtered. The filtrate was evaporated to give 24 g of an oil, 100% yield: 1H-NMR (300 MHz, CDCl3)δ(TMS) 1.37-1.56 (m, 9H), 3.50-3.62 (m, 8H); MS (ESI) m/e 242 (M+H)+.
References:
Astles, Peter C.;Eastwood, Paul R.;Houille, Olivier;Levell, Julian;Pauls, Heinz;Czekaj, Mark;Liang, Guyan;Gong, Yong;Pribish, James;Neuenschwander, Kent US2003/187020, 2003, A1
24424-99-5
849 suppliers
$13.50/25G
334-22-5
11 suppliers
inquiry
118753-70-1
177 suppliers
$6.00/1g
821-48-7
558 suppliers
$6.00/25g
118753-70-1
177 suppliers
$6.00/1g
334-22-5
11 suppliers
inquiry
118753-70-1
177 suppliers
$6.00/1g