N-Boc-N-methylethylenediamine synthesis

13synthesis methods

Product Name:N-Boc-N-methylethylenediamine
CAS Number:121492-06-6
Molecular formula:C8H18N2O2
Molecular Weight:174.24

2-(2-N-BOC-N-METHYL-AMINOETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE

121495-40-7
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121492-06-6
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Yield:121492-06-6 700 mg

Reaction Conditions:

with hydrazine hydrate in methanol for 5 h;Reflux;

Steps:

10 tert-Butyl (2-ami noethyl)(methyl)carbamate
tert-Butyl (2-ami noethyl)(methyl)carbamate Hydrazine hydrate (400, 8 mmol) was added dropwise to a solution of tert-butyl (2- (i,3-dioxoisoindolin-2-yl)ethyl)(methyl)carbamate (i.2 g, 4 mmol) in MeOH (40 mL). Thenthe mixture was stirred at reflux for S h. After cooling to RT, the solution was filtered to remove insoluble materials and the filtrate was concentrated to dryness under reduced pressure to give an oily residue, to which was added CH2CI2 (iOO mL), and then washed with brine (15 ml). The organic solvent was dried (Na2504) and concentrated to dryness to give tert-butyl (2-aminoethyl)(methyl)carbamate (700 mg) as a colorless oil, which wascarried through without further purification.

References:

TEMPERO PHARMACEUTICALS, INC.;GHOSH, Shomir;LOBERA, Mercedes;SCHMIDT, Darby, R.;BALOGLU, Erkan WO2013/6408, 2013, A1 Location in patent:Page/Page column 53

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24424-99-5 Synthesis