ChemicalBook CAS DataBase List N-Boc-L-Histidine

N-Boc-L-Histidine synthesis

11synthesis methods

Product Name:N-Boc-L-Histidine
CAS Number:17791-52-5
Molecular formula:C11H17N3O4
Molecular Weight:255.27

20866-46-0
145 suppliers
$8.00/1g

17791-52-5
286 suppliers
$5.00/1g

Yield:17791-52-5 85.1%

Reaction Conditions:

in ethyl acetate at 50 - 60; for 3 h;Temperature;

Steps:

1-4
The ethyl acetate solution containing the intermediate Na-tert-butoxycarbonyl-Nim-tert-butoxycarbonyl-L-histidine was stirred at 50-60°C for 3 hours. After the reaction, add water and stand for layering, wash the oil phase with water, combine the water phase, filter, concentrate to dryness under reduced pressure, add 200 grams of ethanol, precipitate solids, filter, and dry to obtain the product Nα-tert-butoxycarbonyl-L-histidine 21.7 grams, yield 85.10%, HPLC: 99.95%,

References:

Binhai Jier Polypeptide Co., Ltd.;Sun Xuefeng;Shi Hua;Yan Xing;Chen Wei;Xu Jinyong;Jiang Ping CN111574456, 2020, A Location in patent:Paragraph 0030; 0032-0033; 0035-0036; 0038-0039; 0041

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