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ChemicalBook CAS DataBase List N-BOC-(4-CARBOXYPHENYL)ALANINE
167496-24-4

N-BOC-(4-CARBOXYPHENYL)ALANINE synthesis

2synthesis methods
26496-94-6 Synthesis
Ethyl 4-(bromomethyl)benzoate

26496-94-6
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N-BOC-(4-CARBOXYPHENYL)ALANINE

167496-24-4
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: 1.) NaOEt / 1.) ethanol, 2.) ethanol, 5 h, reflux
2: 1.) aq. NaOH, 2.) acetic acid, 3.) 12 M aq. HCl
3: 64 percent / Et3N / tetrahydrofuran; H2O / 24 h / Ambient temperature

References:

Matsoukas;Agelis;Wahhab;Hondrelis;Panagiotopoulos;Yamdagni;Wu;Mavromoustakos;Maia;Ganter;Moore [Journal of Medicinal Chemistry,1995,vol. 38,# 23,p. 4660 - 4669]

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