N-BENZYLIDENE-N-(DIPHENYLMETHYL)AMINE synthesis

11synthesis methods

Product Name:N-BENZYLIDENE-N-(DIPHENYLMETHYL)AMINE
CAS Number:62506-88-1
Molecular formula:C20H17N
Molecular Weight:271.36

100-52-7 Synthesis

100-52-7
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91-00-9
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62506-88-1
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Yield:62506-88-1 98%

Reaction Conditions:

with magnesium sulfate in dichloromethane at 20;Inert atmosphere;

Steps:

I. Preparation and characterization of imine substrates

General procedure: A flame-dried round-bottom flask, equipped with a stir bar, was charged with benzhydrylamine (1.2 equiv), aldehyde (1.0 equiv), magnesium sulfate (0.40 g/mmol), and dichloromethane (2.0 mL/mmol). The mixture was allowed to stir at room temperature for 6-18 h under nitrogen atmosphere. Upon completion, the reaction mixture was filtered and concentrated. The resulting solid was purified by recrystallization (ethyl acetate/hexanes). 1a: white solid (98%). ¹H NMR (400 MHz, CDCl₃) δ 8.41 (s, 1H), 7.85 - 7.77 (m, 2H), 7.42 - 7.17 (m, 13H), 5.58 (s, 1H).

References:

Shen, Mei-Hua;Guo, Bin;Li, Chen;Sun, Chen-Lei;Zhu, Yi-Fan;Zhu, Chifan;Xu, Hua-Dong;Xu, Defeng [Tetrahedron Letters,2022,vol. 100,art. no. 153886] Location in patent:supporting information

91-00-9
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100-51-6 Synthesis