N-(2,6-dimethylphenyl)-N-propylamine synthesis
- Product Name:N-(2,6-dimethylphenyl)-N-propylamine
- CAS Number:826-99-3
- Molecular formula:C11H17N
- Molecular Weight:163.2594
Yield:826-99-3 79 %
Reaction Conditions:
with C36H25ClN3O3PRuS;potassium hydroxide in toluene at 100;Green chemistry;
Steps:
3.1. General procedure for N-alkylation of aromatic amines with alcohols4
General procedure: Amine (1 mmol), alcohol (1 mmol), catalyst (0.5 mol %), KOH (50 mol %) and toluene (2 mL) were placed in a 25 mL round bottomed flask and stirred on a preheated oil bath (1000C) for 12 h. Upon completion (as monitored by TLC), the reaction mixture was cooled at ambient temperature, H2O (3 mL) was added and the organic layer was extracted with CH2Cl2. The organic extract was separated, dried, and concentrated. The desired product was purified by column chromatography with n-hexane/EtOAc as eluent.
References:
Vijayapritha, Subbarayan;Nithya, Paramasivan;Viswanathamurthi, Periasamy;Raju, Saravanan;Linert, Wolfgang [Polyhedron,2023,vol. 235,art. no. 116351] Location in patent:supporting information
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