Methyl2,4-dichlorothiazole-5-carboxylate synthesis
- Product Name:Methyl2,4-dichlorothiazole-5-carboxylate
- CAS Number:861708-66-9
- Molecular formula:C5H3Cl2NO2S
- Molecular Weight:212.05
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Yield:861708-66-9 79%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 5 h;
Steps:
1
To a solution of compound III (1.04 g, 5.2 mmol), K2CO3 (1.078 g, 7.8 mmol) in DMF (20 ml) was added MeI (0.36 ml, 6.24 mmol). After stirring at room temperature for 5 hours, the mixture was diluted with AcOEt, and washed with water. The organic phase was separated, concentrated in vacuo, and then purified by chromatography on a silica gel column using CHCl3 as an eluant to afford the title compound of formula IV (832 mg, 79%) as a pale yellow solid 1H NMR (400 MHz, CDCl3) ppm 3.91 (s, 3H)
References:
US2009/270456,2009,A1 Location in patent:Page/Page column 8