α-Methyl-5-pyriMidineMethanol synthesis
- Product Name:α-Methyl-5-pyriMidineMethanol
- CAS Number:79691-74-0
- Molecular formula:C6H8N2O
- Molecular Weight:124.1405
75-16-1
270 suppliers
$12.00/10ml
10070-92-5
269 suppliers
$10.00/250mg
79691-74-0
27 suppliers
$125.00/50mg
Yield: 70%
Reaction Conditions:
in tetrahydrofuran at -70; for 1 h;
Steps:
Preparation of A49
To a solution of 44 (100 mg, 0.9 rnmol) in THF (2 mL) is added MgMeBr (1 M, 1.1 mL, 1.1 mmoi) dropwise at --70 °C. After stirring for 1 hour, EtOH (1 rnL) is added at 0 °C and then the mixture is acidified with 2 M HC1 to pH 6. The mixture is then extracted with EA(i0 mL >c 2). The combined organic layers are dried over anhydrous sodium sulfate, filtered, concentrated, and purified by silica gel column chromatography (MeOH:DCM = 1:50) to give A49 as a colorless oil (80 mg, 70% yield). (MS: [M+Hj 125.1)
References:
IMMUNE SENSOR, LLC;THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM;ZHONG, Boyu;SUN, Lijun;SHI, Heping;LI, Jing;CHEN, Chuo;CHEN, Zhijian WO2017/176812, 2017, A1 Location in patent:Paragraph 0275
60025-05-0
10 suppliers
inquiry
79691-74-0
27 suppliers
$125.00/50mg