天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List METHYL 4-(P-NITROPHENOXY)BUTYRATE
28341-53-9

METHYL 4-(P-NITROPHENOXY)BUTYRATE synthesis

1synthesis methods
100-02-7 Synthesis
4-Nitrophenol

100-02-7
17 suppliers
$11.00/5G

4897-84-1 Synthesis
Methyl 4-bromobutyrate

4897-84-1
261 suppliers
$5.00/1g

-

Yield:28341-53-9 2.2 g

Reaction Conditions:

with potassium carbonate;potassium iodide in propan-2-one; for 72 h;Reflux;

Steps:

1.1 Step 1: Synthesis of 4-(4-nitrophenoxy)butanoic acid

In a 100ml 1-neck round flask, 1.5 g (8.29 mmol) of methyl-4-bromobutyrate, 1.15 g (8.29 mmol) of 4-nitrophenol, 1.37 g (9.94 mmol) of potassium carbonate, 100 mg of potassium iodide, and 50 ml of acetone were added. Each is added in turn, and reflux stirring is performed for at least 72 hours. The completion of the reaction was confirmed by TLC, eluent EA: n-hexane (1:4). When the completion of the reaction is confirmed, the reaction solution is first filtered, and the filtrate is concentrated. Dissolve in 50 ml of EA in the concentrate, washed twice with 30 ml of water, washed once with 30 ml of saturated brine, dried over anhydrous MgSO 4 , filtered, and the filtrate is concentrated to an intermediate 2.2 g of methyl 4-(4-nitrophenoxy)butanoate was obtained. Here, the hydrolysis reaction was carried out as follows without further purification. In 200 ml of 2N NaOH MeOH:MC (9:1) solution, the mixture was stirred at room temperature for 4 hours or more to complete the hydrolysis reaction. After adjusting the pH to 1-2 with concentrated hydrochloric acid (35%) and removing the solvent with a vacuum distiller, 50 ml of water was added to the resulting solid, followed by slurry stirring at about 40° C. for 1 hour, followed by filtration. The obtained solid was dried at 55° C. for at least 8 hours to obtain 1.2 g (yield 64.3%) of a pale yellow powder.

References:

KR2022/66701,2022,A Location in patent:Paragraph 0098-0101

METHYL 4-(P-NITROPHENOXY)BUTYRATE Related Search: