methyl 4-amino-2-fluorobenzoate hydrochloride synthesis
- Product Name:methyl 4-amino-2-fluorobenzoate hydrochloride
- CAS Number:1063733-13-0
- Molecular formula:C8H9ClFNO2
- Molecular Weight:205.61
Yield:-
Reaction Conditions:
with hydrogenchloride for 72 h;Reflux;
Steps:
6
Preparation 6; Methyl 4-amino-2-fluorobenzoate hydrochloride; 4-Amino-2-fluorobenzoic acid (preparation 5, 23.9g, 0.154mol) was dissolved in MeOH (50OmL), HCI gas was bubbled through the solution until the boiling point of the solution was reached. The reaction mixture was then heated at reflux for 72 hours. The solvent was evaporated to yield the title compound as a beige solid (33.2g, crude quantitative yield).1HNMR (de-DMSO): 3.68 (s, 3H), 6.21 (br s), 6.44-6.54 (m, 2H), 7.58 (t, 1 H). LCMS (5min) Rt = 1.59min. MS m/z 170 [M+H]+.
References:
WO2010/35166,2010,A1 Location in patent:Page/Page column 69