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ChemicalBook CAS DataBase List METHYL 3-OXOHEPTANOATE
39815-78-6

METHYL 3-OXOHEPTANOATE synthesis

10synthesis methods
-

Yield: 79%

Reaction Conditions:

with calcium hydroxide in dichloromethane;butanone

Steps:

5 EXAMPLE 5
EXAMPLE 5 Under the same conditions as in Example 1, 116 g (1.0 mol) of methyl acetoacetate in a mixture of 520 ml of methylene chloride and 30 ml of methyl ethyl ketone were reacted with 77.8 g (1.05 mol) of calcium hydroxide and 138.7 g (1.15 mol) of valeryl chloride. The pH in this gave 151 g (GC purity 82.5%) of methyl valerylacetate (yield 79.0%).

References:

Wacker-Chemie GmbH US5194671, 1993, A

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